Dual Role of Mitochondrial Porin in Metabolite Transport across the Outer Membrane and Protein Transfer to the Inner Membrane.

@article{Ellenrieder2019DualRO,
  title={Dual Role of Mitochondrial Porin in Metabolite Transport across the Outer Membrane and Protein Transfer to the Inner Membrane.},
  author={Lars Ellenrieder and Martin Philipp Dieterle and Kim Nguyen Doan and Christoph U. M{\aa}rtensson and Alessia Floerchinger and Mar{\'i}a Luisa Campo and Nikolaus Pfanner and Thomas Becker},
  journal={Molecular cell},
  year={2019},
  volume={73 5},
  pages={
          1056-1065.e7
        }
}
The mitochondrial inner membrane harbors a large number of metabolite carriers. The precursors of carrier proteins are synthesized in the cytosol and imported into mitochondria by the translocase of the outer membrane (TOM) and the carrier translocase of the inner membrane (TIM22). Molecular chaperones in the cytosol and intermembrane space bind to the hydrophobic precursors to prevent their aggregation. We report that the major metabolite channel of the outer membrane, termed porin or voltage… CONTINUE READING

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