Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A.

@article{Besnard2011DualRO,
  title={Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A.},
  author={Anne-Gaelle Besnard and Robert Sabat and Laure Dumoutier and Jean-Christophe Renauld and Monique A. M. Willart and Bart Lambrecht and Mauro M Teixeira and Sabine Charron and Lizette Fick and François Erard and Katarzyna Warszawska and Kerstin Wolk and Val{\'e}rie F J Quesniaux and Bernhard Ryffel and Dieudonn{\'e}e Togb{\'e}},
  journal={American journal of respiratory and critical care medicine},
  year={2011},
  volume={183 9},
  pages={1153-63}
}
RATIONALE IL-22 has both proinflammatory and antiinflammatory properties. Its role in allergic lung inflammation has not been explored. OBJECTIVES To investigate the expression and roles of IL-22 in the onset and resolution of experimental allergic asthma and its cross-talk with IL-17A. METHODS IL-22 expression was assessed in patient samples and in the lung of mice immunized and challenged with ovalbumin. IL-22 functions in allergic airway inflammation were evaluated using mice deficient… CONTINUE READING