Dual Role of GM-CSF as a Pro-Inflammatory and a Regulatory Cytokine: Implications for Immune Therapy.

@article{Bhattacharya2015DualRO,
  title={Dual Role of GM-CSF as a Pro-Inflammatory and a Regulatory Cytokine: Implications for Immune Therapy.},
  author={Palash Bhattacharya and Isadore Budnick and Medha Singh and Muthusamy Thiruppathi and Khaled Alharshawi and Hatem A. Elshabrawy and Mark J. Holterman and Bellur S Prabhakar},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2015},
  volume={35 8},
  pages={585-99}
}
Granulocyte macrophage colony stimulating factor (GM-CSF) is generally recognized as an inflammatory cytokine. Its inflammatory activity is primarily due its role as a growth and differentiation factor for granulocyte and macrophage populations. In this capacity, among other clinical applications, it has been used to bolster anti-tumor immune responses. GM-CSF-mediated inflammation has also been implicated in certain types of autoimmune diseases, including rheumatoid arthritis and multiple… CONTINUE READING
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