Dual Role of CO2/HCO3− Buffer in the Regulation of Intracellular pH of Three-dimensional Tumor Growths*

@inproceedings{Hulkov2011DualRO,
  title={Dual Role of CO2/HCO3− Buffer in the Regulation of Intracellular pH of Three-dimensional Tumor Growths*},
  author={Alzbeta Hul{\'i}kov{\'a} and Richard D. Vaughan-Jones and Pawel Swietach},
  booktitle={The Journal of biological chemistry},
  year={2011}
}
Intracellular pH (pH(i)), a major modulator of cell function, is regulated by acid/base transport across membranes. Excess intracellular H(+) ions (e.g. produced by respiration) are extruded by transporters such as Na(+)/H(+) exchange, or neutralized by HCO(3)(-) taken up by carriers such as Na(+)-HCO(3)(-) cotransport. Using fluorescence pH(i) imaging, we show that cancer-derived cell lines (colorectal HCT116 and HT29, breast MDA-MB-468, pancreatic MiaPaca2, and cervical HeLa) extrude acid by… CONTINUE READING

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