Dual Role for Fas Ligand in the Initiation of and Recovery from Experimental Allergic Encephalomyelitis

@article{SabelkoDownes1999DualRF,
  title={Dual Role for Fas Ligand in the Initiation of and Recovery  from Experimental Allergic Encephalomyelitis },
  author={Kimberly A. Sabelko-Downes and Anne H. Cross and John H. Russell},
  journal={The Journal of Experimental Medicine},
  year={1999},
  volume={189},
  pages={1195 - 1205}
}
We have previously demonstrated a role for Fas and Fas ligand (FasL) in the pathogenesis of experimental allergic encephalomyelitis (EAE). However, using an active induction paradigm we could not distinguish between FasL expressed on activated CD4(+) T cells from that expressed on other inflammatory or resident central nervous system (CNS) cells. To address… CONTINUE READING