Dual Mode of Action of Dihydropyridine Calcium Antagonists

  title={Dual Mode of Action of Dihydropyridine Calcium Antagonists},
  author={Dr Stefan Dhein and Aida Salameh and Reinhard Berkels and Wolfgang HRIBERNIK Klaus},
Dihydropyridine calcium antagonists have been used for many years in the treatment of angina pectoris and hypertension. According to the common view, their mechanism of action is based on an inhibition of the smooth muscle L-type calcium current, thus decreasing intracellular calcium concentration and inducing smooth muscular relaxation. However, in recent years evidence has accumulated that besides the smooth muscle effects of these agents, their effect on the endothelium must also to be taken… CONTINUE READING


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