Dual Functions of ASCIZ in the DNA Base Damage Response and Pulmonary Organogenesis

  title={Dual Functions of ASCIZ in the DNA Base Damage Response and Pulmonary Organogenesis},
  author={Sabine Jurado and Ian Smyth and Bryce van Denderen and Nora Tenis and Andrew Hammet and Kimberly Kappler Hewitt and Jane-Lee Ng and Carolyn J. McNees and Sergei V. Kozlov and Hayato Oka and Masahiko Kobayashi and Lindus A. Conlan and Timothy J Cole and Ken-ichi Yamamoto and Yoshihito Taniguchi and Shunichi Takeda and Martin Francis Lavin and J{\"o}rg Heierhorst},
  booktitle={PLoS genetics},
Zn²(+)-finger proteins comprise one of the largest protein superfamilies with diverse biological functions. The ATM substrate Chk2-interacting Zn²(+)-finger protein (ASCIZ; also known as ATMIN and ZNF822) was originally linked to functions in the DNA base damage response and has also been proposed to be an essential cofactor of the ATM kinase. Here we show that absence of ASCIZ leads to p53-independent late-embryonic lethality in mice. Asciz-deficient primary fibroblasts exhibit increased… CONTINUE READING


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