Dual Effect of Serum Amyloid A on the Invasiveness of Glioma Cells

@inproceedings{Knebel2013DualEO,
  title={Dual Effect of Serum Amyloid A on the Invasiveness of Glioma Cells},
  author={Franciele Hinterholz Knebel and Renata Chaves Albuquerque and Renato Ramos Massaro and Silvya Stuchi Maria-Engler and Ana M. Sanchez de la Campa},
  booktitle={Mediators of inflammation},
  year={2013}
}
Evidence sustains a role for the acute-phase protein serum amyloid A (SAA) in carcinogenesis and metastasis, and the protein has been suggested as a marker for tumor progression. Nevertheless, the demonstration of a direct activity of SAA on tumor cells is still incipient. We have investigated the effect of human recombinant SAA (rSAA) on two human glioma cell lines, A172 and T98G. rSAA stimulated the [(3)H]-thymidine incorporation of both lines, but had dual effects on migration and… CONTINUE READING