DsrA RNA regulates translation of RpoS message by an anti-antisense mechanism, independent of its action as an antisilencer of transcription.

@article{Majdalani1998DsrARR,
  title={DsrA RNA regulates translation of RpoS message by an anti-antisense mechanism, independent of its action as an antisilencer of transcription.},
  author={Nadim Majdalani and Christofer Cunning and Darren D Sledjeski and Tony Elliott and Susan Gottesman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 21},
  pages={12462-7}
}
DsrA RNA regulates both transcription, by overcoming transcriptional silencing by the nucleoid-associated H-NS protein, and translation, by promoting efficient translation of the stress sigma factor, RpoS. These two activities of DsrA can be separated by mutation: the first of three stem-loops of the 85 nucleotide RNA is necessary for RpoS translation but not for anti-H-NS action, while the second stem-loop is essential for antisilencing and less critical for RpoS translation. The third stem… CONTINUE READING
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