Dscam diversity is essential for neuronal wiring and self-recognition

  title={Dscam diversity is essential for neuronal wiring and self-recognition},
  author={D. Hattori and Ebru Demir and Ho Won Kim and Erika Vir{\'a}gh and S Lawrence Zipursky and Barry J. Dickson},
Neurons are thought to use diverse families of cell-surface molecules for cell recognition during circuit assembly. In Drosophila, alternative splicing of the Down syndrome cell adhesion molecule (Dscam) gene potentially generates 38,016 closely related transmembrane proteins of the immunoglobulin superfamily, each comprising one of 19,008 alternative ectodomains linked to one of two alternative transmembrane segments. These ectodomains show isoform-specific homophilic binding, leading to… CONTINUE READING