Dry reagent-based polymerase chain reaction compared with other laboratory methods available for the diagnosis of Buruli ulcer disease.

@article{Siegmund2007DryRP,
  title={Dry reagent-based polymerase chain reaction compared with other laboratory methods available for the diagnosis of Buruli ulcer disease.},
  author={Vera Siegmund and Ohene Adjei and Joerg Nitschke and William Thompson and Erasmus Y Klutse and Karl Heinz Herbinger and Ruth M Thompson and Felicitas van Vloten and Paul Racz and Bernhard Fleischer and Thomas L{\"o}scher and Gisela Bretzel},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2007},
  volume={45 1},
  pages={68-75}
}
BACKGROUND Because of the multifaceted clinical presentation of Buruli ulcer disease, misclassification of clinically diagnosed cases may occur frequently. Laboratory tests for the confirmation of suspected cases include microscopic examination, culture, polymerase chain reaction (PCR), and histopathologic examination. However, microscopic examination, the only test usually available in areas of endemicity, has a low sensitivity. METHODS To make a highly sensitive diagnostic method locally… CONTINUE READING
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