Dry powder inhalers: the influence of device resistance and powder formulation on drug and lactose deposition in vitro.

@article{Srichana1998DryPI,
  title={Dry powder inhalers: the influence of device resistance and powder formulation on drug and lactose deposition in vitro.},
  author={T. Srichana and G. P. Martin and C. Marriott},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={1998},
  volume={7 1},
  pages={
          73-80
        }
}
  • T. Srichana, G. P. Martin, C. Marriott
  • Published 1998
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
It is a principal in the formulation of a dry powder aerosol that the device should enable a high fine particle fraction (FPF) of drug to be delivered to the lung whilst any carrier, such as lactose, should remain in the upper airways. Both the device and the dry powder formulation itself contribute to the resultant FPF and few studies have considered the deposition of lactose carrier. It was the purpose of this study to determine the effect of the resistance of the device and the influence of… Expand
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