Dry powder inhalation of macromolecules using novel PEG-co-polyester microparticle carriers.

@article{Tawfeek2013DryPI,
  title={Dry powder inhalation of macromolecules using novel PEG-co-polyester microparticle carriers.},
  author={Hesham M Tawfeek and Andrew R Evans and Abid Iftikhar and Afzal R Mohammed and Anjum Shabir and Satyanarayana Somavarapu and Gillian Ann Hutcheon and Imran Y. Saleem},
  journal={International journal of pharmaceutics},
  year={2013},
  volume={441 1-2},
  pages={611-9}
}
This study investigated optimizing the formulation parameters for encapsulation of a model mucinolytic enzyme, α-chymotrypsin (α-CH), within a novel polymer; poly(ethylene glycol)-co-poly(glycerol adipate-co-ω-pentadecalactone), PEG-co-(PGA-co-PDL) which were then applied to the formulation of DNase I. α-CH or DNase I loaded microparticles were prepared via spray drying from double emulsion (w(1)/o/w(2)) utilizing chloroform (CHF) as the organic solvent, L-leucine as a dispersibility enhancer… CONTINUE READING
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