Dry powder inhalation formulation of chitosan nanoparticles for co-administration of isoniazid and pyrazinamide

  title={Dry powder inhalation formulation of chitosan nanoparticles for co-administration of isoniazid and pyrazinamide},
  author={Narumon Changsan and Chutima Sinsuebpol},
  journal={Pharmaceutical Development and Technology},
  pages={181 - 192}
Abstract Co-loaded isoniazid and pyrazinamide chitosan nanoparticles were formulated using the ionic gelation method. The formulations were adjusted to five mass ratios of tripolyphosphate (TPP) and chitosan at three TPP concentrations. Particle size, polydispersity index, zeta potential, and encapsulation efficiency were used to evaluate all formulations. The results revealed that the ratio of TPP to chitosan had the highest impact in generating chitosan nanoparticles. The selected… 
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