Dry Eye as a Mucosal Autoimmune Disease

  title={Dry Eye as a Mucosal Autoimmune Disease},
  author={Michael Ethan Stern and Chris S. Schaumburg and Stephen Carl Pflugfelder},
  booktitle={International reviews of immunology},
Dry eye is a common ocular surface inflammatory disease that significantly affects quality of life. Dysfunction of the lacrimal function unit (LFU) alters tear composition and breaks ocular surface homeostasis, facilitating chronic inflammation and tissue damage. Accordingly, the most effective treatments to date are geared towards reducing inflammation and restoring normal tear film. The pathogenic role of CD4+ T cells is well known, and the field is rapidly realizing the complexity of other… CONTINUE READING
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Ocular surface antigen presenting cells are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis

  • CS Schaumburg, KF Siemasko, CS de Paiva
  • J Immunol
  • 2011
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