Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers.

@article{Luibl2006DrusenDA,
  title={Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers.},
  author={Volker Luibl and Jose Mario Isas and Rakez Kayed and Charles G. Glabe and Ralf Langen and Jeannie Chen},
  journal={The Journal of clinical investigation},
  year={2006},
  volume={116 2},
  pages={378-85}
}
Protein misfolding and aggregation are thought to underlie the pathogenesis of many amyloid diseases, such as Alzheimer and Parkinson diseases, whereby a stepwise protein misfolding process begins with the conversion of soluble protein monomers to prefibrillar oligomers and progresses to the formation of insoluble amyloid fibrils. Drusen are extracellular deposits found in aging eyes and in eyes afflicted with age-related macular degeneration (AMD). Recent characterizations of drusen have… CONTINUE READING
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