Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease

@article{Mullins2000DrusenAW,
  title={Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease},
  author={Robert F. Mullins and Stephen R. Russell and Don H. Anderson and Gregory S. Hageman},
  journal={The FASEB Journal},
  year={2000},
  volume={14},
  pages={835 - 846}
}
Age‐related macular degeneration (AMD), a blinding disorder that compromises central vision, is characterized by the accumulation of extracellular deposits, termed drusen, between the retinal pigmented epithelium and the choroid. Recent studies in this laboratory revealed that vitronectin is a major component of drusen. Because vitronectin is also a constituent of abnormal deposits associated with a variety of diseases, drusen from human donor eyes were examined for compositional similarities… Expand
The Alzheimer's Aβ-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration
TLDR
It is shown that Aβ is associated with a substructural vesicular component within drusen, which could be an important component of the local inflammatory events that contribute to atrophy of the retinal pigmented epithelium, Drusen biogenesis, and the pathogenesis of AMD. Expand
Drusen proteome analysis: An approach to the etiology of age-related macular degeneration
TLDR
Data strongly support the hypothesis that oxidative injury contributes to the pathogenesis of AMD and suggest that oxidative protein modifications may have a critical role in drusen formation. Expand
Characterization of β amyloid assemblies in drusen: The deposits associated with aging and age-related macular degeneration
Abstract Purpose . Recent studies strongly suggest that drusen, the extracellular deposits associated with age-related macular degeneration (AMD), are a manifestation of local inflammatory events.Expand
Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers.
TLDR
The presence of nonfibrillar, toxic oligomers in drusen is observed and similar protein misfolding processes may occur in AMD and amyloid diseases. Expand
Age-related macular degeneration: clinical findings, histopathology and imaging techniques.
TLDR
Modern ocular imaging technologies enable one to follow changes in the RPE, photoreceptors, and choriocapillaris quantitatively as the disease progresses and provide useful measures of treatment efficacy that are likely to be more sensitive and reproducible than conventional end points such as visual acuity and rate of enlargement of geographic atrophy. Expand
Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology.
TLDR
Recent research has revealed that the disease-associated 402H allotype interacts less well with binding sites within the macula, which could result in impaired regulation of complement leading to chronic local inflammation that may contribute to the accumulation of drusen and thus the initiation, development and progression of AMD. Expand
Systemic levels of C-reactive protein in patients with age-related macular degeneration: A systematic review with meta-analyses
TLDR
This review provides an overview of this extensively studied field, provides summary estimates that provide insight into when and to what extent systemic C-reactive protein is associated with age-related macular degeneration, and helps in distinguishing the potentially reversible disease processes from that of irreversible retinal ageing. Expand
Sub-retinal drusenoid deposits in human retina: organization and composition.
We demonstrate histologically sub-retinal drusenoid debris in three aged human eyes, two of them affected by age-related maculopathy. By postmortem fundus examination, the lesions were drusen-like,Expand
An Integrated Hypothesis That Considers Drusen as Biomarkers of Immune-Mediated Processes at the RPE-Bruch's Membrane Interface in Aging and Age-Related Macular Degeneration
TLDR
An integrated ultrastructural, histochemical, molecular biological, and biochemical approach is described to identify specific molecular pathways associated with drusen biogenesis and invokes, for the first time, the potential for a direct role of cell- and immune-mediated processes in drusens biogenesis. Expand
Localization of complement 1 inhibitor (C1INH/SERPING1) in human eyes with age-related macular degeneration.
TLDR
Results indicate that C1INH protein is present in the retina and choroid, where it may regulate complement activation, and is associated with AMD affection status. Expand
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TLDR
RT‐PCR analyses revealed that vitronectin mRNA is expressed in the retinal pigmented epithelium (RPE)‐choroidal complex and cultured RPE cells, and it is proposed that vitRONectin is a major constituent of human ocular drusen and that vitronsen mRNA is synthesized locally, and may participate in the pathogenesis of AMD. Expand
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TLDR
Different phenotypes of drusen, although they may differ significantly with respect to their substructural morphology, may possess a similar complement of extracellular matrix-associated proteins and saccharides. Expand
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TLDR
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TLDR
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TLDR
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