Drugs used in the treatment of attention-deficit/hyperactivity disorder affect postsynaptic firing rate and oscillation without preferential dopamine autoreceptor action

@article{Ruskin2001DrugsUI,
  title={Drugs used in the treatment of attention-deficit/hyperactivity disorder affect postsynaptic firing rate and oscillation without preferential dopamine autoreceptor action},
  author={David N Ruskin and Debra A Bergstrom and Andrew Shenker and Lauren E Freeman and Judith R. Walters},
  journal={Biological Psychiatry},
  year={2001},
  volume={49},
  pages={340-350}
}
BACKGROUND Current theories propose that low doses of catecholaminergic stimulants reduce symptoms in patients with attention-deficit/hyperactivity disorder by acting on autoreceptors to reduce catecholaminergic transmission; few data are available that directly address this hypothesis. METHODS We investigated the autoreceptor and postsynaptic receptor actions of systemically administered stimulants on dopaminergic systems in rats with single-unit recording in the substantia nigra pars… CONTINUE READING

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