Drugs that target dynamic microtubules: a new molecular perspective.

@article{Stanton2011DrugsTT,
  title={Drugs that target dynamic microtubules: a new molecular perspective.},
  author={Richard A. Stanton and Kim M. Gernert and James H. Nettles and Ritu Aneja},
  journal={Medicinal research reviews},
  year={2011},
  volume={31 3},
  pages={443-81}
}
Microtubules have long been considered an ideal target for anticancer drugs because of the essential role they play in mitosis, forming the dynamic spindle apparatus. As such, there is a wide variety of compounds currently in clinical use and in development that act as antimitotic agents by altering microtubule dynamics. Although these diverse molecules are known to affect microtubule dynamics upon binding to one of the three established drug domains (taxane, vinca alkaloid, or colchicine site… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 220 references

New microtubule-inhibiting anticancer agents.

Expert opinion on investigational drugs • 2010
View 5 Excerpts
Highly Influenced

Microtubule dynamics as a target in oncology.

Cancer treatment reviews • 2009
View 5 Excerpts
Highly Influenced

Antimitotic natural products and their interactions with tubulin.

Medicinal research reviews • 1996
View 10 Excerpts
Highly Influenced

Variations in the colchicine-binding domain provide insight into the structural switch of tubulin.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 4 Excerpts
Highly Influenced

TIP maker and TIP marker; EB1 as a master controller of microtubule plus ends

The Journal of cell biology • 2005
View 4 Excerpts
Highly Influenced

Microtubules as a target for anticancer drugs

Nature Reviews Cancer • 2004
View 4 Excerpts
Highly Influenced

Antimicrotubular drugs binding to vinca domain of tubulin

Molecular and Cellular Biochemistry • 2003
View 5 Excerpts
Highly Influenced

Structural insight into microtubule function.

Annual review of biophysics and biomolecular structure • 2001
View 3 Excerpts
Highly Influenced

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