Drugs of abuse and their metabolites in waste and surface waters by liquid chromatography-tandem mass spectrometry.

@article{Pedrouzo2011DrugsOA,
  title={Drugs of abuse and their metabolites in waste and surface waters by liquid chromatography-tandem mass spectrometry.},
  author={Marta Pedrouzo and Francesc Borrull and Eva Pocurull and Rosa Maria Marc{\'e}},
  journal={Journal of separation science},
  year={2011},
  volume={34 10},
  pages={1091-101}
}
A solid-phase extraction and liquid chromatography-tandem mass spectrometry (SPE/LC-MS-MS) method was developed and validated for the simultaneous determination of nicotine, five drugs of abuse (morphine, cocaine, codeine, methadone, and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine) and four metabolites (dihydrocodeine, 6-acetylmorphine, 11-nor-carboxy-Δ(9)-tetrahydrocannabinol, and benzoylecgonine) in water samples. A Fused-Core™ particle column was used as an alternative to sub-2-μm… CONTINUE READING
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