Drugs in porphyria: From observation to a modern algorithm-based system for the prediction of porphyrogenicity.

@article{Hift2011DrugsIP,
  title={Drugs in porphyria: From observation to a modern algorithm-based system for the prediction of porphyrogenicity.},
  author={Richard J. Hift and Stig Thunell and Atle Brun},
  journal={Pharmacology & therapeutics},
  year={2011},
  volume={132 2},
  pages={
          158-69
        }
}
The acute porphyrias are a group of disorders which result from inherited defects in the enzymes of the heme biosynthetic pathway. Affected patients are prone to potentially fatal acute attacks. These attacks are frequently precipitated by exposure to commonly used drugs. Correctly identifying the safety or otherwise of drugs in porphyria is therefore important. In this review we describe how clinical experience and the findings of experimental systems using whole animal or cell culture models… CONTINUE READING

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