Drugs in early clinical development for the treatment of female sexual dysfunction

@article{Belkin2015DrugsIE,
  title={Drugs in early clinical development for the treatment of female sexual dysfunction},
  author={Zoe R. Belkin and Jill M Krapf and Andrew T Goldstein},
  journal={Expert Opinion on Investigational Drugs},
  year={2015},
  volume={24},
  pages={159 - 167}
}
Introduction: There is growing recognition of female sexual dysfunction (FSD) as an important women’s health concern. Despite an increased awareness of the pathophysiologic components to FSD, currently, there are no drugs approved for the most common sexual complaint in women–decreased sexual desire. In response to an overwhelming demand for therapy for FSD, several drugs are undergoing development and testing. Areas covered: The aim of this paper is to provide the latest data on… 
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Advances in pharmacotherapy for treating female sexual dysfunction
TLDR
The paper reports the most recent advances in pharmacotherapy for women taking into account the biopsychosocial model and discusses the potential use of on-demand combined hormonal (testosterone) and non-hormonal (buspirone or sildenafil) treatments to address possible neurophysiological profiles of women.
Pharmacotherapy for female sexual dysfunctions (FSDs): What is on the market and where is this field heading?
TLDR
The authors report the most recent advances in pharmacotherapy for premenopausal and postmenopausal women with a main focus on hypoactive sexual desire disorders (HSDD) and associated sexual symptoms.
Tadalafil once daily: Narrative review of a treatment option for female sexual dysfunctions (FSD) in midlife and older women.
  • C. Borghi, L. Dell’Atti
  • Psychology, Medicine
    Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
  • 2017
TLDR
What is already known about the use of these vasoactive agents, particularly tadalafil, as a treatment option for female sexual disturbances is reviewed and phosphodiesterase type 5 inhibitors could be an effective option for many subtypes of female sexual disorders.
Female Sexual Dysfunction-Medical and Psychological Treatments, Committee 14.
The Female Sexual Response: Current Models, Neurobiological Underpinnings and Agents Currently Approved or Under Investigation for the Treatment of Hypoactive Sexual Desire Disorder
TLDR
Evolving treatment strategies have relied heavily on these crucial research findings, as many of the agents currently being investigated as treatment options for HSDD target and influence key players within these excitatory and inhibitory pathways, including various hormone therapies and centrally acting drugs.
Medical Treatment of Female Sexual Dysfunction.
Hypoactive Sexual Desire Disorder: A Review of Epidemiology, Biopsychology, Diagnosis, and Treatment.
Future Targets for Female Sexual Dysfunction.
Future Directions in Sexual Medicine
TLDR
The pharmacological approach continues to be a mainstay of therapy, but an increased focus on psychosocial and lifestyle factors is beginning to play a pivotal role in creating a more balanced approach to the treatment of sexual dysfunction.
Evaluation and Treatment of Sexual Disorders Due to Medical Conditions
TLDR
This chapter discusses epidemiology, etiology, pathophysiology, diagnostic criteria, and best evidence-based practice and approaches to the diagnosis of sexual disorders due to medical conditions, and provides a review of diagnostic tests frequently used by physicians to aid in diagnosis and monitoring of treatment outcomes for sexual disorders.
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