Drugs from the deep: marine natural products as drug candidates.

@article{Haefner2003DrugsFT,
  title={Drugs from the deep: marine natural products as drug candidates.},
  author={Burkhard Haefner},
  journal={Drug discovery today},
  year={2003},
  volume={8 12},
  pages={
          536-44
        }
}
In recent years, marine natural product bioprospecting has yielded a considerable number of drug candidates. Most of these molecules are still in preclinical or early clinical development but some are already on the market, such as cytarabine, or are predicted to be approved soon, such as ET743 (Yondelis). Research into the ecology of marine natural products has shown that many of these compounds function as chemical weapons and have evolved into highly potent inhibitors of physiological… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 72 references

Antiangiogenic activity of aeroplysinin-1, a brominated compound isolated from a marine sponge

S Rodriguez-Nieto
FASEB J • 2002

Aplidin TM induces the mitochondrial apoptotic pathway via oxidative stressmediated JNK and p 38 activation and protein kinase C δ

A. Cuadrado
Oncogene • 2002

Chemical diversity: independent of functional diversity

M. Tulp, L. Bohlin
Trends Pharmacol. Sci • 2002