Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myelosuppressed mice: their comparison and joint effects with the granulocyte colony-stimulating factor.

@article{Hofer2002DrugsEE,
  title={Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myelosuppressed mice: their comparison and joint effects with the granulocyte colony-stimulating factor.},
  author={Michal Hofer and Milan Posp{\'i}{\vs}il and Vladim{\'i}r Znojil and Anton{\'i}n Vacek and Lenka Weiterov{\'a} and Jirina Hol{\'a} and Jiř{\'i} V{\'a}cha},
  journal={European journal of haematology},
  year={2002},
  volume={68 1},
  pages={4-11}
}
We tested capabilities of drugs elevating extracellular adenosine and of granulocyte colony-stimulating factor (G-CSF) given alone or in combination to modulate regeneration from severe myelosuppression resulting from combined exposure of mice to ionizing radiation and carboplatin. Elevation of extracellular adenosine was induced by joint administration of dipyridamole (DP), a drug inhibiting the cellular uptake of adenosine, and adenosine monophosphate (AMP), serving as an adenosine prodrug… CONTINUE READING
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