Drugs as CYP3A probes, inducers, and inhibitors.

@article{Liu2007DrugsAC,
  title={Drugs as CYP3A probes, inducers, and inhibitors.},
  author={Yi-tong Liu and Haiping Hao and Changxiao Liu and Guang-ji Wang and Hong-Guang Xie},
  journal={Drug metabolism reviews},
  year={2007},
  volume={39 4},
  pages={699-721}
}
Human cytochrome P450 (CYP) 3A subfamily members (mainly CYP3A4 and CYP3A5) mediate the metabolism of approximately half all marketed drugs and thus play a critical role in the drug metabolism. A huge number of studies on CYP3A-mediated drug metabolism in humans have demonstrated that CYP3A activity exhibits marked ethnic and individual variability, in part because of altered levels of CYP3A4 expression by various environmental factors and functionally important polymorphisms present in CYP3A5… CONTINUE READING

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