Drugs and their molecular targets: an updated overview

@article{Landry2008DrugsAT,
  title={Drugs and their molecular targets: an updated overview},
  author={Yves D Landry and J. -P. Gies},
  journal={Fundamental \& Clinical Pharmacology},
  year={2008},
  volume={22}
}
About 330 targets bind approved drugs, 270 encoded by the human genome and 60 belonging to pathogenic organisms. A large number of druggable targets have been recently proposed from preclinical and first clinical data, but a huge reservoir of putative drug targets, possibly several thousands, remains to be explored. This overview considers the different types of ligands and their selectivity in the main superfamilies of drug targets, enzymes, membrane transporters and ion channels, and the… Expand
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