Drugs acting on homeostasis: challenging cancer cell adaptation

  title={Drugs acting on homeostasis: challenging cancer cell adaptation},
  author={Maria M Moschovi and Elena Critselis and Osman Çen and Maria Adamaki and George I. Lambrou and George P. Chrousos and Spiros A Vlahopoulos},
  journal={Expert Review of Anticancer Therapy},
  pages={1405 - 1417}
Cancer treatment aims to exploit properties that define malignant cells. In recent years, it has become apparent that malignant cells often survive cancer treatment and ensuing cell stress by switching on auxiliary turnover pathways, changing cellular metabolism and, concomitantly, the gene expression profile. The changed profile impacts the material exchange of cancer cells with affected tissues. Herein, we show that pathways of proteostasis and energy generation regulate common transcription… 

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