Drugs acting on homeostasis: challenging cancer cell adaptation

@article{Moschovi2015DrugsAO,
  title={Drugs acting on homeostasis: challenging cancer cell adaptation},
  author={M. Moschovi and E. Critselis and Osman Çen and M. Adamaki and G. Lambrou and G. Chrousos and S. Vlahopoulos},
  journal={Expert Review of Anticancer Therapy},
  year={2015},
  volume={15},
  pages={1405 - 1417}
}
Cancer treatment aims to exploit properties that define malignant cells. In recent years, it has become apparent that malignant cells often survive cancer treatment and ensuing cell stress by switching on auxiliary turnover pathways, changing cellular metabolism and, concomitantly, the gene expression profile. The changed profile impacts the material exchange of cancer cells with affected tissues. Herein, we show that pathways of proteostasis and energy generation regulate common transcription… Expand
Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways
TLDR
The work addressing the role of chloroquines in the homeostasis of mammalian tissue, and the potential strengths and weaknesses concerning their use in cancer therapy are reviewed. Expand
The Autophagy-Lysosomal Pathways and Their Emerging Roles in Modulating Proteostasis in Tumors
TLDR
In this review, insights are provided into the proteostatic process and how it is regulated by the ALPs, such as macroautophagy, aggrephagy, chaperone-mediated autophagy. Expand
Cancer as a defective network for NF-κB
TLDR
The role of the transcription factor NF-κB, which interacts with chromatin modulators by cell-specific dynamics, controls cell interactions during inflammation, and its abnormal feedback regulation is implicated in cancer, is addressed. Expand
Hsp90 facilitates acquired drug resistance of tumor cells through cholesterol modulation however independent of tumor progression.
TLDR
The findings suggest that drug efflux activity and metastatic potential of tumor cells are independently regulated by Hsp90 by distinct mechanisms, and expose the limitations imposed by HSp90 inhibitors against multidrug resistant tumor cells. Expand
Inflammation and tissue homeostasis: the NF-κB system in physiology and malignant progression
TLDR
Disruption of key feedback modules for NF-κB in certain cell types facilitates the survival of clones with genomic aberrations, and protects them from being recognized and eliminated by the immune system, to enable thereby carcinogenesis. Expand
Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode
TLDR
The molecular mode of NF-κB regulation with a few characteristic examples of target genes is described, which enables profound local changes in tissue function and composition. Expand
Pro-apoptotic peptides-based cancer therapies: challenges and strategies to enhance therapeutic efficacy
TLDR
This review will overview the developed pro-apoptotic peptides and outline the widely adopted molecular-based and nanoparticle-based strategies to enhance their anti-tumor effects. Expand
Targeting breast cancer stem-like cells using Chloroquine encapsulated by a Triphenylphosphonium-functionalized hyperbranched polymer.
TLDR
This study suggests that breast cancer stem cells, as they are modeled by mammospheres, are sensitive to encapsulated chloroquine, depending on the expression of the ATM kinase, which is thereby characterized as a potential biomarker for sensitivity to this type of treatment. Expand
Danshen extract circumvents drug resistance and represses cell growth in human oral cancer cells
  • Cheng-Yu Yang, C. Hsieh, +6 authors Yuan-Wu Chen
  • Chemistry, Medicine
  • BMC Complementary and Alternative Medicine
  • 2017
TLDR
The study results suggest that the Danshen extract could be a potential anticancer agent in oral cancer treatment. Expand
Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy
TLDR
The cutting-edge progresses in liposomal NPs for cancer immunotherapy, with focus on dendritic cells, T cells, tumor cells, natural killer cells, and macrophages are summarized. Expand
...
1
2
...

References

SHOWING 1-10 OF 138 REFERENCES
Molecular Pathways: Targeting MYC-induced Metabolic Reprogramming and Oncogenic Stress in Cancer
TLDR
Combined targeting of multiple MYC-mediated pathways, especially those involved in regulating cell proliferation, metabolism, and oncogenic stress, are considered to be promising based on multiple preclinical studies. Expand
Calcium Homeostasis and ER Stress in Control of Autophagy in Cancer Cells
TLDR
Autophagy modulation might be promising in anticancer therapies; however, it is a context-dependent matter whether inhibition or activation of autophagy leads to tumor cell death. Expand
Small heat shock proteins in cancer therapy and prognosis.
TLDR
The rationale for Hsp27 and sCLU as therapeutic targets in cancer is reviewed, the current status of pre-clinical and clinical studies using HSp27 and CLU inhibitors, OGX-427 and OGX -011, respectively are updated. Expand
Induction of the Unfolded Protein Response Drives Enhanced Metabolism and Chemoresistance in Glioma Cells
TLDR
Detailed analysis of UPR transcriptional/translational/metabolic responses in glioma cells and human tumors is reported, linking the UPR to chemoresistance possibly via enhanced metabolism. Expand
Glucocorticoid and proteasome inhibitor impact on the leukemic lymphoblast: Multiple, diverse signals converging on a few key downstream regulators
TLDR
Results from several ongoing studies indicate convergence of genomically diverse signal pathways to a limited number of key downstream regulators of apoptosis, which can be exploited to address the problem of genetic heterogeneity in acute leukemia. Expand
Calcium Channel Expression and Applicability as Targeted Therapies in Melanoma
TLDR
Not only do Ca2+ channels appear to have a potential as prognostic markers, but their pharmacological blockade or gene silencing is hinted as interesting therapeutic approaches. Expand
Metabolic changes in cancer: beyond the Warburg effect.
TLDR
Some of the cancer-associated metabolic disorders and current understanding of their molecular tumorigenic mechanisms are introduced. Expand
Interleukin-6
TLDR
It is hypothesized that autophagy mediates PCa NED in the bone and identified interleukin-6 (IL-6), a cytokine more highly expressed in HS5 cells than in HS27a cells, as a paracrine factor that regulates PCa Autophagy. Expand
Myc inhibition impairs autophagosome formation
TLDR
It is shown that Myc depletion inhibits autophagosome formation and impairs clearance of autophagy substrates, and the data suggest that targeting Myc in cancer therapy might have the additional benefit of inhibitingAutophagy in the case of therapy resistance associated with chemotherapy-induced autophapy. Expand
Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment.
TLDR
Study of NF-κB actually leads to a far more dynamic perspective on cancer: tumors caused by diverse oncogenes apparently evolve into cancer after loss of feedback regulation for NF-σ, which alters the cellular phenotype and the expression of hormonal mediators. Expand
...
1
2
3
4
5
...