Drugs acting on homeostasis: challenging cancer cell adaptation

@article{Moschovi2015DrugsAO,
  title={Drugs acting on homeostasis: challenging cancer cell adaptation},
  author={Maria M Moschovi and Elena Critselis and Osman Çen and Maria Adamaki and George I. Lambrou and George P. Chrousos and Spiros A Vlahopoulos},
  journal={Expert Review of Anticancer Therapy},
  year={2015},
  volume={15},
  pages={1405 - 1417}
}
Cancer treatment aims to exploit properties that define malignant cells. In recent years, it has become apparent that malignant cells often survive cancer treatment and ensuing cell stress by switching on auxiliary turnover pathways, changing cellular metabolism and, concomitantly, the gene expression profile. The changed profile impacts the material exchange of cancer cells with affected tissues. Herein, we show that pathways of proteostasis and energy generation regulate common transcription… 

Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways

TLDR
The work addressing the role of chloroquines in the homeostasis of mammalian tissue, and the potential strengths and weaknesses concerning their use in cancer therapy are reviewed.

The Autophagy-Lysosomal Pathways and Their Emerging Roles in Modulating Proteostasis in Tumors

TLDR
In this review, insights are provided into the proteostatic process and how it is regulated by the ALPs, such as macroautophagy, aggrephagy, chaperone-mediated autophagy.

Cancer as a defective network for NF-κB

TLDR
The role of the transcription factor NF-κB, which interacts with chromatin modulators by cell-specific dynamics, controls cell interactions during inflammation, and its abnormal feedback regulation is implicated in cancer, is addressed.

Inflammation and tissue homeostasis: the NF-κB system in physiology and malignant progression

TLDR
Disruption of key feedback modules for NF-κB in certain cell types facilitates the survival of clones with genomic aberrations, and protects them from being recognized and eliminated by the immune system, to enable thereby carcinogenesis.

Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode

TLDR
The molecular mode of NF-κB regulation with a few characteristic examples of target genes is described, which enables profound local changes in tissue function and composition.

Pro-apoptotic peptides-based cancer therapies: challenges and strategies to enhance therapeutic efficacy

TLDR
This review will overview the developed pro-apoptotic peptides and outline the widely adopted molecular-based and nanoparticle-based strategies to enhance their anti-tumor effects.

Danshen extract circumvents drug resistance and represses cell growth in human oral cancer cells

TLDR
The study results suggest that the Danshen extract could be a potential anticancer agent in oral cancer treatment.

Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy

TLDR
The cutting-edge progresses in liposomal NPs for cancer immunotherapy, with focus on dendritic cells, T cells, tumor cells, natural killer cells, and macrophages are summarized.

References

SHOWING 1-10 OF 138 REFERENCES

Molecular Pathways: Targeting MYC-induced Metabolic Reprogramming and Oncogenic Stress in Cancer

TLDR
Combined targeting of multiple MYC-mediated pathways, especially those involved in regulating cell proliferation, metabolism, and oncogenic stress, are considered to be promising based on multiple preclinical studies.

Calcium Homeostasis and ER Stress in Control of Autophagy in Cancer Cells

TLDR
Autophagy modulation might be promising in anticancer therapies; however, it is a context-dependent matter whether inhibition or activation of autophagy leads to tumor cell death.

Small heat shock proteins in cancer therapy and prognosis.

Induction of the Unfolded Protein Response Drives Enhanced Metabolism and Chemoresistance in Glioma Cells

TLDR
Detailed analysis of UPR transcriptional/translational/metabolic responses in glioma cells and human tumors is reported, linking the UPR to chemoresistance possibly via enhanced metabolism.

Calcium Channel Expression and Applicability as Targeted Therapies in Melanoma

TLDR
Not only do Ca2+ channels appear to have a potential as prognostic markers, but their pharmacological blockade or gene silencing is hinted as interesting therapeutic approaches.

Metabolic changes in cancer: beyond the Warburg effect.

TLDR
Some of the cancer-associated metabolic disorders and current understanding of their molecular tumorigenic mechanisms are introduced.

Interleukin-6

TLDR
It is hypothesized that autophagy mediates PCa NED in the bone and identified interleukin-6 (IL-6), a cytokine more highly expressed in HS5 cells than in HS27a cells, as a paracrine factor that regulates PCa Autophagy.

Myc inhibition impairs autophagosome formation

TLDR
It is shown that Myc depletion inhibits autophagosome formation and impairs clearance of autophagy substrates, and the data suggest that targeting Myc in cancer therapy might have the additional benefit of inhibitingAutophagy in the case of therapy resistance associated with chemotherapy-induced autophapy.

Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment.

...