Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

  title={Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.},
  author={Gaetano Di Chiara and Assunta Dr Imperato},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={85 14},
  • G. Di Chiara, A. Imperato
  • Published 1 July 1988
  • Biology, Psychology
  • Proceedings of the National Academy of Sciences of the United States of America
The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus accumbens septi (a limbic area) and the dorsal caudate nucleus (a subcortical motor area), was studied in freely moving rats by using brain dialysis. Drugs abused by humans (e.g., opiates, ethanol, nicotine, amphetamine, and cocaine) increased extracellular dopamine concentrations in both areas, but especially in the accumbens, and elicited hypermotility at low doses. On… 

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Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour.
  • U. Ungerstedt
  • Biology
    Acta physiologica Scandinavica. Supplementum
  • 1971
Amphetamine induced vigorous rotational behaviour in rats where the nigrostriatal dopamine system was unilaterally degenerated by an intracerebral injection of 6-hydroxydopamine (6-OH-DA) and evidence was obtained that the amphetamine induced release of DA was dependent upon nerve impulses.
Pharmacologic characterization of nicotine-induced conditioned place preference
Brain Res . 94 , 507 - 522
  • 1975
Handbook ofDrug Abuse
  • Natl. Inst. Drug Abuse, U.S. Gov. Print. Off
  • 1979
The Rat Brain
  • 1963