Drugging topoisomerases: lessons and challenges.

@article{Pommier2013DruggingTL,
  title={Drugging topoisomerases: lessons and challenges.},
  author={Yves Pommier},
  journal={ACS chemical biology},
  year={2013},
  volume={8 1},
  pages={
          82-95
        }
}
Topoisomerases are ubiquitous enzymes that control DNA supercoiling and entanglements. They are essential during transcription and replication, and topoisomerase inhibitors are among the most effective and most commonly used anticancer and antibacterial drugs. This review consists of two parts. In the first part ("Lessons"), it gives background information on the catalytic mechanisms of the different enzyme families (6 different genes in humans and 4 in most bacteria), describes the… CONTINUE READING
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