Druggable sensors of the unfolded protein response.

  title={Druggable sensors of the unfolded protein response.},
  author={Dustin J Maly and Feroz R. Papa},
  journal={Nature chemical biology},
  volume={10 11},
The inability of cells to properly fold, modify and assemble secretory and transmembrane proteins leads to accumulation of misfolded proteins in the endoplasmic reticulum (ER). Under these conditions of 'ER stress', cell survival depends on homeostatic benefits from an intracellular signaling pathway called the unfolded protein response (UPR). When activated, the UPR induces transcriptional and translational programs that restore ER homeostasis. However, under high-level or chronic ER stress… CONTINUE READING
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