Druggability of human disease genes.

  title={Druggability of human disease genes.},
  author={Meena Kishore Sakharkar and Kishore R. Sakharkar and Shazib Pervaiz},
  journal={The international journal of biochemistry & cell biology},
  volume={39 6},
The availability of complete genome sequences and the wealth of large-scale biological datasets provide an unprecedented opportunity to elucidate the genetic basis of human diseases. Here we use integrative in silico approaches to provide an accurate description of gene functions to a set of 1737 highly curated disease genes in the human genome. This analysis is the first attempt on in silico identification of druggable domains within disease genes. We provide information on gene architecture… CONTINUE READING