Drug treatment of the negative symptoms of schizophrenia

@article{King1998DrugTO,
  title={Drug treatment of the negative symptoms of schizophrenia},
  author={David John King},
  journal={European Neuropsychopharmacology},
  year={1998},
  volume={8},
  pages={33-42}
}
  • D. King
  • Published 1 February 1998
  • Psychology, Medicine
  • European Neuropsychopharmacology

Atypical Antipsychotics as First-Line Treatments for Schizophrenia

Current guidelines recommend the use of atypical antipsychotics as first-line treatments in a wide range of patients with schizophrenia, despite significant caveats regarding the quality of evidence to support use of these drugs in general.

Current therapy issues and unmet clinical needs in the treatment of schizophrenia: a review of the new generation antipsychotics

The results from clinical trials suggest that atypical agents improve negative and affective symptoms, and cognitive functioning more than typical antipsychotics, but that the pattern of effects on these domains, as well as on suicidality, appears to differ.

The new and evolving pharmacotherapy of schizophrenia.

Quetiapine has equivalent efficacy and superior tolerability to risperidone in the treatment of schizophrenia with predominantly negative symptoms

In conclusion, there is no significant difference in efficacy between quetiapine and risperidone in alleviating the negative symptoms of schizophrenia.

Long-term efficacy and safety of quetiapine in treatment-refractory schizophrenia: A case report

A 58-year-old man suffering from chronic therapy-resistant schizophrenia, with both positive and negative symptoms, who was successfully treated with quetiapine for 5 years is presented, the first report of such long beneficial use of quet iapine in a hospital clinical practice.

Long-term efficacy and safety of quetiapine in treatment-refractory schizophrenia: A case report.

A 58-year-old man suffering from chronic therapy-resistant schizophrenia, with both positive and negative symptoms, who was successfully treated with quetiapine for 5 years is presented, the first report of such long beneficial use of quet iapine in a hospital clinical practice.

Novel antipsychotics: issues and controversies. Typicality of atypical antipsychotics.

  • E. Stip
  • Psychology, Medicine
    Journal of psychiatry & neuroscience : JPN
  • 2000
New-generation neuroleptic agents were found to have greater efficacy on the negative symptoms of schizophrenia and to cause fewer unwanted extrapyramidal side effects than the traditional antipsychotic drugs.

Efficacy of Olanzapine and Ziprasidone for the Treatment of Schizophrenia

Both drugs appear to be superior to placebo for the treatment of overall and negative symptoms of schizophrenia, but olanzapine generally compares more favourably with conventional antipsychotics.

The Ideal Antipsychotic: Hybrid between Typical Haloperidol And the Atypical Clozapine Antipsychotic

The design of a “hybrid structure” having the desired properties of haloperidol and clozapine is proposed, with the intention being to find an optimal antipsychotic agent that exerts efficient therapeutic effects against both positive and negative symptoms of psychosis causing least possible side effects, such as in monotherapy.

Antipsychotic treatment in schizophrenia: atypical options and NICE guidance

...

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These ’atypical’ antipsychotic drugs appear to have significant advantages over older drugs, such as haloperidol and chlorpromazine, in particular, they induce significantly less extrapyramidal side effects (EPS), produce less mood impairment and may directly attenuate negative as well as positive symptoms of schizophrenia.

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The chief evidence for this position is that clozapine (CLOZ) does not differ from typical antipsychotic drugs in these regards but is more effective than typical neuroleptic drugs.
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