Drug treatment of epilepsy in the century of the ILAE: The second 50 years, 1959–2009
@article{Shorvon2009DrugTO, title={Drug treatment of epilepsy in the century of the ILAE: The second 50 years, 1959–2009}, author={Simon D. Shorvon}, journal={Epilepsia}, year={2009}, volume={50} }
The drug therapy of epilepsy evolved enormously in this 50 year period. Advances in therapeutics included the incorporation of pharmacokinetics into clinical practice, enormous advances in neurochemistry, a trend to antiepileptic drug monotherapy, better drug assessment, better understanding of therapeutic outcomes, and the recognition of the large epilepsy treatment gap in many countries. An unprecedented range of new drugs was introduced in this period. Before 1989, these included…
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References
SHOWING 1-10 OF 272 REFERENCES
Principles for Clinical Testing of Antiepileptic Drugs
- Medicine, PsychologyEpilepsia
- 1973
These principles are intended to improve the quality of the clinical evaluation of new antiepileptic drugs and to facilitate the international exchange of data supporting the investigation of new anti-epileptic agents, resulting in the more rapiddevelopment and precise use of new drugs for the treatment of epilepsy.
Ethosuximide in the treatment of epilepsy.
- Medicine, PsychologyJAMA
- 1962
The third succinimide, ethosuximide (Zarontin), was found to be highly protective against pentylenetetrazol (Metrazol)-induced seizures in experimental animals.
Results of treatment changes in patients with apparently drug‐resistant chronic epilepsy
- Psychology, MedicineAnnals of neurology
- 2007
The aim of this study was to quantify the effect of adding a previously unused antiepileptic drug to the treatment regimen in adults with uncontrolled chronic epilepsy that had been resistant to previous antIEpileptic drug treatment.
Progress report on new antiepileptic drugs A summary of the Second Eilat Conference
- BiologyEpilepsy Research
- 1995
We Live in the Age of the Clinical Guideline
- Medicine, Political ScienceEpilepsia
- 2006
The intention is to put the case for the opposition and to articulate the negative, to incite critical thought and to sound an alarm on the general issue of guidelines and on the broader consequences of the authors' “guideline” culture.
Double-blind study of vigabatrin in the treatment of drug-resistant epilepsy.
- Medicine, PsychologyArchives of neurology
- 1987
The results demonstrate the efficacy and good tolerability of vigabatrin therapy in patients with severe complex partial epilepsy and show a significant reduction in seizure frequency during treatment.
The temporal aspects of prognosis in epilepsy.
- Medicine, PsychologyJournal of neurology, neurosurgery, and psychiatry
- 1984
In this paper prognostic studies in a variety of areas are reviewed to emphasise this point that the traditional view of epilepsy as a chronic condition with a continuing tendency to relapse is not tenable for the majority of patients.
Vigabatrin vs carbamazepine monotherapy in patients with newly diagnosed epilepsy. A randomized, controlled study.
- Medicine, PsychologyArchives of neurology
- 1995
Vigabatrin seems to be an effective and safe antiepileptic drug as primary monotherapy for epilepsy with fewer cognitive side effects than carbamazepine and Retrieval from both episodic and semantic memory and flexibility of mental processing improved significantly in patients successfully treated with vigab atrin.
Natural history of treated childhood-onset epilepsy: prospective, long-term population-based study.
- Medicine, PsychologyBrain : a journal of neurology
- 2006
It is concluded that half the patients with childhood-onset epilepsy will eventually enter terminal remission without relapse and a fifth after relapse, and one-third will have a poor long-term outcome in terms of persistent seizures after remission or without any remission ever.
Antiepileptic Drug Development Program: A Cooperative Effort of Government and Industry
- BiologyEpilepsia
- 1989
In vivo tests, featuring amygdala‐ and corneal‐kindled seizures, and in vitro assays, define drug‐drug interactions and elucidate the pharmacological profiles of potential anticonvulsants.