Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier.

@article{Demeule2002DrugTT,
  title={Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier.},
  author={Michel Demeule and Anthony R{\'e}gina and Julie Jodoin and Alain Laplante and Claude Dagenais and France Berthelet and Albert Moghrabi and Richard B{\'e}liveau},
  journal={Vascular pharmacology},
  year={2002},
  volume={38 6},
  pages={339-48}
}
1. The blood-brain barrier (BBB) contributes to brain homeostastis and fulfills a protective function by controlling the access of solutes and toxic substances to the central nervous system (CNS). The efflux transporter P-glycoprotein (P-gp) is a key element of the molecular machinery that confers special permeability properties to the BBB. 2. P-gp, which was initially recognized for its ability to expel anticancer drugs from multidrug-resistant cancer cells, is strongly expressed in brain… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 58 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 106 references

Expression of multidrug resistanceassociatedprotein ( MRP ) in brainmicrovessel endothelial cells

  • H. Huai-Yun, D. T. Secrest, K. S. Mark, D. Carney, C. Brandquist, D. W. Miller
  • Biochem . Biophys . Res . Commun .
  • 1998
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…