Drug transport at the blood-brain barrier and the choroid plexus.

@article{Graff2004DrugTA,
  title={Drug transport at the blood-brain barrier and the choroid plexus.},
  author={Candace L. Graff and Gary M. Pollack},
  journal={Current drug metabolism},
  year={2004},
  volume={5 1},
  pages={95-108}
}
The blood-brain barrier (BBB) and blood-CSF barrier (BCSFB) represent the main interfaces between the central nervous system (CNS) and the peripheral circulation. Drug exposure to the CNS is dependent on a variety of factors, including the physical barrier presented by the BBB and the BCSFB and the affinity of the substrate for specific transport systems located at both of these interfaces. It is the aggregate effect of these factors that ultimately determines the total CNS exposure, and thus… CONTINUE READING