Drug-transport and volume-activated chloride channel functions in human erythroleukemia cells: Relation to expression level of P-glycoprotein

@article{Viana1995DrugtransportAV,
  title={Drug-transport and volume-activated chloride channel functions in human erythroleukemia cells: Relation to expression level of P-glycoprotein},
  author={F{\'e}lix Viana and Kristel Van Acker and Christine De Greef and Jan Eggermont and Luc Raeymaekers and Guy Droogmans and Bernd Nilius},
  journal={The Journal of Membrane Biology},
  year={1995},
  volume={145},
  pages={87-98}
}
The characteristics of volume-activated chloride currents, drug transport function and levels of P-glycoprotein (PgP) expression were compared between two human chronic erythroleukemia cell lines: a parental (K562) cell line and a derivative obtained by vinblastine selection (K562 VBL400). Parental K562 cells showed no detectable P-glycoprotein expression, measured at the protein level (immunofluorescence labeling with monoclonal antibodies), and had very low levels of MDR-1 mRNA expression (RT… CONTINUE READING
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