Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders. Report of the NIMH Collaborative Study Group comparing lithium carbonate, imipramine, and a lithium carbonate-imipramine combination.

@article{Prien1984DrugTI,
  title={Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders. Report of the NIMH Collaborative Study Group comparing lithium carbonate, imipramine, and a lithium carbonate-imipramine combination.},
  author={Robert F. Prien and David Jerome Kupfer and Peter A. Mansky and J. G. Chris Small and Vicente B Tuason and Cai'lyle B. Voss and Walter E Johnson},
  journal={Archives of general psychiatry},
  year={1984},
  volume={41 11},
  pages={1096-104}
}
In a double-blind, long-term follow-up study, 117 bipolar patients received lithium carbonate, imipramine hydrochloride, or both and 150 unipolar patients received lithium carbonate, imipramine, both lithium carbonate and imipramine, or placebo. With bipolar patients, lithium carbonate and the combination treatment were superior to imipramine in preventing manic recurrences and were as effective as imipramine in preventing manic recurrences and were as effective as imipramine in preventing… CONTINUE READING
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