• Corpus ID: 58067341

Drug therapies in neonates and children during extracorporeal membrane oxygenation (ECMO)

@inproceedings{Wildschut2010DrugTI,
  title={Drug therapies in neonates and children during extracorporeal membrane oxygenation (ECMO)},
  author={Enno Diederik Wildschut},
  year={2010}
}
  • E. Wildschut
  • Published 2 July 2010
  • Medicine, Engineering, Biology
__Abstract__ Extracorporeal life support (ECLS) or extra corporeal membrane oxygenation (ECMO) is a technique for providing life support in severe but potentially reversible cardiorespiratory failure in patients with an expected mortality greater than 80%. First pioneered in cardiopulmonary bypass during cardiac surgery, ECLS has been used as prolonged cardiopulmonary support in neonates since 1976. It has been shown to have a survival benefit in neonates and adults. Increasingly ECMO… 

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TLDR
It is concluded that gentamicin and probably other aminoglycosides should be given at dose rates about 25% lower than usual and at longer dosing intervals in patients undergoing ECMO therapy.
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TLDR
In comparison with previously published data, the neonates undergoing ECMO in this study demonstrated a much larger volume of distribution, a lower clearance, and consequently a longer vancomycin half-life, suggesting alterations in the pharmacokinetics of vancomYcin in infants on ECMO.
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