Drug therapies for attentional disorders alter the signal-to-noise ratio in the superior colliculus.

@article{Dommett2009DrugTF,
  title={Drug therapies for attentional disorders alter the signal-to-noise ratio in the superior colliculus.},
  author={Eleanor J. Dommett and Paul G. Overton and Susan A. Greenfield},
  journal={Neuroscience},
  year={2009},
  volume={164 3},
  pages={1369-76}
}
Despite high levels of use, the mechanism of action of effective pharmacotherapies in attention deficit hyperactivity disorder (ADHD) is unknown. It has recently been hypothesized that one site of therapeutic action is the midbrain superior colliculus, a structure traditionally associated with visual processing, but also strongly implicated in distractibility, a core symptom of ADHD. We used male juvenile Wistar rats to examine the effects of therapeutically relevant doses of methylphenidate… CONTINUE READING
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