Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress.

  title={Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress.},
  author={Twan Lammers and Fabian Kiessling and Wim E Hennink and Gert Storm},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={161 2},
Many different systems and strategies have been evaluated for drug targeting to tumors over the years. Routinely used systems include liposomes, polymers, micelles, nanoparticles and antibodies, and examples of strategies are passive drug targeting, active drug targeting to cancer cells, active drug targeting to endothelial cells and triggered drug delivery. Significant progress has been made in this area of research both at the preclinical and at the clinical level, and a number of (primarily… CONTINUE READING
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