Drug targeting: anti-HSV-1 activity of mannosylated polymer-bound 9-(2-phosphonylmethoxyethyl)adenine.

@article{Midoux1990DrugTA,
  title={Drug targeting: anti-HSV-1 activity of mannosylated polymer-bound 9-(2-phosphonylmethoxyethyl)adenine.},
  author={Patrick Midoux and Eric N{\`e}gre and A. C. Roche and Roger Mayer and M. Monsigny and Jan Balzarini and Eric De Clercq and Erwin Mayer and Abdul Ghaffar and J. David Gangemi},
  journal={Biochemical and biophysical research communications},
  year={1990},
  volume={167 3},
  pages={1044-9}
}
The antiviral drug, 9-(2-phosphonylmethoxyethyl) adenine (PMEA) was linked to a synthetic and neutral polymer bearing mannosyl residues to allow its internalization by macrophages via membrane lectins. PMEA bound to the mannosylated polymer was more efficient in vitro than free PMEA in preventing lysis of human macrophages by herpes virus.