Drug susceptibilities of yeast cells are affected by membrane lipid composition.

@article{Mukhopadhyay2002DrugSO,
  title={Drug susceptibilities of yeast cells are affected by membrane lipid composition.},
  author={Kasturi Mukhopadhyay and Avmeet Kohli and Rajendra Prasad},
  journal={Antimicrobial agents and chemotherapy},
  year={2002},
  volume={46 12},
  pages={3695-705}
}
In the present study we have exploited isogenic erg mutants of Saccharomyces cerevisiae to examine the contribution of an altered lipid environment on drug susceptibilities of yeast cells. It is observed that erg mutants, which possess high levels of membrane fluidity, were hypersensitive to the drugs tested, i.e., cycloheximide (CYH), o-phenanthroline, sulfomethuron methyl, 4-nitroquinoline oxide, and methotrexate. Most of the erg mutants except mutant erg4 were, however, resistant to… CONTINUE READING