Drug solubilizers to aid pharmacologists: amorphous cyclodextrin derivatives.

Abstract

Conversion of crystalline alpha-, beta-, or gamma-cyclodextrins into amorphous mixtures of water soluble derivatives yields non-toxic solubilizers which dissolve drugs through the formation of inclusion complexes. From these types of compounds 2-hydroxypropyl ethers of cyclodextrins have presently been investigated and the ranges for the safe use in working with (a) receptor binding assays on membrane preparations, (b) cells in vitro, and (c) parenteral use in mice were established for these compounds. The drugs which were investigated were dissolved in amounts linearly proportionate to the concentration of the solubilizers used and did not precipitate upon dilution by aqueous media. These solubilizers may considerably facilitate pharmacological evaluation of new, water insoluble potential drugs.

Showing 1-10 of 37 extracted citations

Statistics

0100200300'95'98'01'04'07'10'13'16
Citations per Year

1,384 Citations

Semantic Scholar estimates that this publication has received between 512 and 2,938 citations based on the available data.

See our FAQ for additional information.