Drug sensitivity of individual rats determines degree of drug discrimination.

Abstract

Rats were observed to learn to discriminate between the stimulus properties of intraperitoneal 0.16 mg/kg apomorphine and saline, in a two-lever operant task, at different rates. Half of the 12 rats reached criterion performance in a mean of 22.5 session, whereas the other half reached criterion in a mean of 44.2 sessions. These two groups, i.e., the early and later learners, were tested with a range of apomorphine doses and the former group had an ED50 of 0.01 mg/kg, whereas the later group generated an ED50 of 0.07 mg/kg apomorphine. These results suggest that the early learners were significantly more sensitive to apomorphine than the later learners and this may explain the discrepancies in the drug-discrimination literature regarding different ED50's generated at the same drug training dose.

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@article{Schechter1983DrugSO, title={Drug sensitivity of individual rats determines degree of drug discrimination.}, author={Mark D Schechter}, journal={Pharmacology, biochemistry, and behavior}, year={1983}, volume={19 1}, pages={1-4} }