Drug sensitivity of individual rats determines degree of drug discrimination.


Rats were observed to learn to discriminate between the stimulus properties of intraperitoneal 0.16 mg/kg apomorphine and saline, in a two-lever operant task, at different rates. Half of the 12 rats reached criterion performance in a mean of 22.5 session, whereas the other half reached criterion in a mean of 44.2 sessions. These two groups, i.e., the early and later learners, were tested with a range of apomorphine doses and the former group had an ED50 of 0.01 mg/kg, whereas the later group generated an ED50 of 0.07 mg/kg apomorphine. These results suggest that the early learners were significantly more sensitive to apomorphine than the later learners and this may explain the discrepancies in the drug-discrimination literature regarding different ED50's generated at the same drug training dose.


Citations per Year

1,305 Citations

Semantic Scholar estimates that this publication has 1,305 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Schechter1983DrugSO, title={Drug sensitivity of individual rats determines degree of drug discrimination.}, author={Mark D Schechter}, journal={Pharmacology, biochemistry, and behavior}, year={1983}, volume={19 1}, pages={1-4} }