Drug-sensitive FGFR2 mutations in endometrial carcinoma.

  title={Drug-sensitive FGFR2 mutations in endometrial carcinoma.},
  author={Amit Dutt and Helga Birgitte Salvesen and T Chen and Alex H. Ramos and Robert C. Onofrio and Charlie Hatton and Richard Nicoletti and Wendy Winckler and Rupinder Grewal and Megan C. Hanna and Nicolas Wyhs and Liuda Ziaugra and Daniel J Richter and Jone Trovik and Ingeborg B Engelsen and Ingunn Marie Stefansson and Tim Fennell and Kristian Cibulskis and Michael C. Zody and Lars Andreas Akslen and Stacey Bolk Gabriel and Kwok-kin Wong and William R Sellers and Matthew L Meyerson and H. -G. Greulich},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 25},
Oncogenic activation of tyrosine kinases is a common mechanism of carcinogenesis and, given the druggable nature of these enzymes, an attractive target for anticancer therapy. Here, we show that somatic mutations of the fibroblast growth factor receptor 2 (FGFR2) tyrosine kinase gene, FGFR2, are present in 12% of endometrial carcinomas, with additional instances found in lung squamous cell carcinoma and cervical carcinoma. These FGFR2 mutations, many of which are identical to mutations… CONTINUE READING
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