Drug response, dihydrofolate reductase, and cytogenetics of amethopterin-resistant Chinese hamster cells in vitro.


A graded series of amethopterin-resistant sublines maintained at concentrations varying from 0.1 to 50.0 j.zg/ml were selected in vitro from several parental Chinese hamster lines. Increases in resistance ranged from 45to 108,400-fold. Dose-response data for sensitive and resistant populations demonstrated that the 3 parental lines responded identically to… (More)

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