Drug-resistant microorganisms with a higher fitness--can medicines boost pathogens?

@article{Vanaerschot2013DrugresistantMW,
  title={Drug-resistant microorganisms with a higher fitness--can medicines boost pathogens?},
  author={Manu Vanaerschot and Saskia Decuypere and Maya Berg and Syamal Roy and J. Cl. Dujardin},
  journal={Critical reviews in microbiology},
  year={2013},
  volume={39 4},
  pages={
          384-94
        }
}
Drug-resistant microorganisms (DRMs) are generally thought to suffer from a fitness cost associated with their drug-resistant trait, inflicting them a disadvantage when the drug pressure reduces. However, Leishmania resistant to pentavalent antimonies shows traits of a higher fitness compared to its sensitive counterparts. This is likely due the combination of an intracellular pathogen and a drug that targets the parasite's general defense mechanisms while at the same time stimulating the host… CONTINUE READING
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Resistance to antimonials in natural Leishmania populations is associated with heterogeneous molecular adaptations

S Decuypere, M Vanaerschot, +5 authors GH. Coombs
  • PLoS Negl Trop Dis,
  • 2012
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Antimonial resistance in Leishmania donovani is associated with increased in vivo parasite burden

M Vanaerschot, S De Doncker, +3 authors S. Decuypere
  • PLoS ONE,
  • 2011
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Infectiousness, reproductive fitness and evolution of drug-resistant Mycobacterium tuberculosis.

  • The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
  • 2009
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL