Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237.

@article{Sloane2010DrugresistantAA,
  title={Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237.},
  author={Dominic A Sloane and Michael Z. Triki{\'c} and Matthew L H Chu and Maria B A C Lamers and Clive S. Mason and Ilka M{\"u}ller and Wendy J Savory and David H Williams and Patrick A Eyers},
  journal={ACS chemical biology},
  year={2010},
  volume={5 6},
  pages={563-76}
}
The Aurora kinases regulate multiple aspects of mitotic progression, and their overexpression in diverse tumor types makes them appealing oncology targets. An intensive research effort over the past decade has led to the discovery of chemically distinct families of small molecule Aurora kinase inhibitors, many of which have demonstrated therapeutic potential in model systems. These agents are also important tools to help dissect signaling pathways that are orchestrated by Aurora kinases, and… CONTINUE READING

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