Drug resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum malaria in Mlimba, Tanzania

@article{Mbugi2006DrugRT,
  title={Drug resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum malaria in Mlimba, Tanzania},
  author={Erasto Vitus Mbugi and Benezeth M. Mutayoba and Allen Lewis Malisa and Sakurani T Balthazary and Thomas Nyambo and Hassan M Mshinda},
  journal={Malaria Journal},
  year={2006},
  volume={5},
  pages={94 - 94}
}
Sulphadoxine-pyrimethamine (SP) has been and is currently used for treatment of uncomplicated Plasmodium falciparum malaria in many African countries. Nevertheless, the response of parasites to SP treatment has shown significant variation between individuals. The genes for dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) were used as markers, to investigate parasite resistance to SP in 141 children aged less than 5 years. Parasite DNA was extracted by Chelex method from blood… CONTINUE READING