Drug resistance patterns, genetic subtypes, clinical features, and risk factors in military personnel with HIV-1 seroconversion.

@article{Brodine1999DrugRP,
  title={Drug resistance patterns, genetic subtypes, clinical features, and risk factors in military personnel with HIV-1 seroconversion.},
  author={Stephanie K. Brodine and R. A. Shaffer and M J Starkey and Sybil A. Tasker and Joyce L Gilcrest and Mark K. Louder and Amy Barile and Thomas C. Vancott and Maryanne T. Vahey and Francine E. McCutchan and Deborah L. Birx and Douglas D. Richman and John R. Mascola},
  journal={Annals of internal medicine},
  year={1999},
  volume={131 7},
  pages={
          502-6
        }
}
Genetic variability is a central feature of HIV-1. The high frequency of mutations during HIV-1 replication leads to the development of viral quasi-species in vivo and contributes to genetic heterogeneity among HIV-1 isolates (1, 2). There is a growing appreciation that HIV-1 genetic diversity, including the existence of distinct genetic subtypes and the evolution of drug-resistant genotypes, can greatly affect the diagnosis and treatment of HIV-1 infection (1, 2). On the basis of DNA sequence… CONTINUE READING

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